Dr Dinah Parums Publications

PUBLICATIONS – Dr Dinah Parums

Peer Reviewed Clinical and Research Papers:

Parums DV. Monograph: Current Status of Targeted Therapy in Non Small-Cell Lung Cancer (NSCLC). Drugs Today 2014, 50(7): 503-517. Available at: https://www.academia.edu/10248939/Current_Status_of_Targeted_Therapy_in_Non_Small_Cell_Lung_Cancer_NSCLC_

Parums DV. Invited Review: Status of Immune Therapy in Non Small-Cell Lung Cancer (NSCLC). Drugs Future 2014, 39(7): 469 – 475. Available at:  https://www.academia.edu/14478210/Status_of_Immune_Therapy_in_Non-Small_Cell_Lung_Cancer_NSCLC_

Donovan MJ, Kotsianti A, Bayer-Zubek V, Verbel D, Teverovskiy M, Cordon-Cardo C, Costa J, Greco FA, Hainsworth JD, Parums DV.   A systems pathology model for predicting overall survival in patients with refractory, advanced non small-cell lung cancer treated with gefitinib. Eur J Cancer, 2009 May;45(8):1518-26. Available at: https://www.academia.edu/7643757/A_systems_pathology_model_for_predicting_overall_survival_in_patients_with_refractory_advanced_non-small-cell_lung_cancer_treated_with_gefitinib

Hirsch FR, Dziadziuszko R, Thatcher N, Mann H, Watkins C, Parums DV, Speake G, Holloway B, Bunn Jr PA, Franklin WA. Epidermal Growth Factor Immunohistochemistry: Comparison of Antibodies and Cut-off Points to Predict Benefit from Gefitinib in a Phase III Placebo-Controlled Study in Advanced Non-Small Cell Lung Cancer. Cancer, 2008, 112(5):1114-21. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355966/

Hirsch FR, Varella-Garcia M, Bunn PA Jr, Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums DV, Botwood, Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol. 2006 Nov 1;24(31):5034-42. Available at: http://jco.ascopubs.org/content/24/31/5034.long

Lindop GBM, Burke MM, Ogston S, Bishop P, Corbishley C, Goddard M, Harrison R, Kjellstrom C, McPhaden A, Malone M, Parums DV, Suvarna K, Stewart S. Inter-observer variability in grading acute rejection in endomyocardial biopsies. J Heart and Lung Transplantation 2003; Supp v22 n1 S96. Available at: http://www.worldcat.org/title/inter-observer-variability-in-grading-acute-rejection-in-endomyocardial-biopsies/oclc/4933925381

Torsney E, Charlton R, Parums DV, Collis M, Arthur HM. Inducible expression of human endoglin during inflammation and wound healing in vivo. Inflamm Res 2002;51:464-70. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12365720

Katz SD, Parums DV. Sympathetic activation by sildenafil. Circulation 2001;104:119-200. Available at: http://circ.ahajournals.org/content/104/22/e119.long

Ray-Chaudhuri N, Kine DA, Tijani SO, Parums DV, Cartlidge N, Strong NP, Dayan MR. Effect of prior steroid treatment on temporal artery biopsy findings in giant cell arteritis. Br J Ophthalmol. 2002;86:530-2. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771122/

Luckraz H, Parums DV, Dunning J. Reverse saphenous interposition vein graft repair of a giant atherosclerotic aneurysm of the left anterior descending coronary artery. J Thorac Cardiovasc Surg 2002;123:817-20. Available at: http://www.jtcvsonline.org/article/S0022-5223(02)80294-X/fulltext

De Soyza AG, Dark JH, Parums DV, Curtis A, Corris PA. Donor-acquired small cell lung cancer following pulmonary transplantation. Chest 2001;120:1030-1. Available at: http://journal.publications.chestnet.org/article.aspx?articleid=1079938

Katz SD, Parums DV. Sympathetic activation by sildenafil. Circulation 2001;104:119-200. http://circ.ahajournals.org/content/104/22/e119.full

Arthur H, Torsney E, Ure J, Smith A, Wilson D, Charlton RG, Parums DV, Jowett T, Burn J, Diamond A.  Endoglin, a ancillary TGF Beta Receptor, is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development.  Developmental Biology 2000;217:42-53. Available at: http://www.sciencedirect.com/science/article/pii/S0012160699995349

Pagano D, Townend JN, Parums DV, Bonser RS, Camici PG. Hibernating Myocardium: Morphological Correlates of Inotropic Stimulation and Glucose Uptake. Heart  2000;83:456-461. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729369/

Dr Dinah Parums - Combined IHC (CD31) and NISH (TGFbeta)

Dr Dinah Parums – Combined IHC (CD31) and NISH (TGFbeta)

Dr Dinah Parums and Richard Charlton. Poster Prize, July 2000. Pathological Society of Great Britain & Ireland.

Dr Dinah Parums and Richard Charlton. Poster Prize, July 2000. Pathological Society of Great Britain & Ireland.

Kumar, R.P.Smith, D.A., Hilton, C.J. and Parums, D.V. A Case of Epithelioid Haemangioendothelioma (EHE) of the Lung with Bronchial Brushing Cytology. Cytopathology  1999;10:132-6. Available at: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2303.1999.00111.x/abstract

Crilley, J.G., Owens, W.A., Parums, D.V. A Dissection with a Difference: An Unusual Case of Ascending Aortic Dissection Secondary to Granulomatous Aortitis. Hosp Med 1998;59:892-3. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10197126

Parums, D.V. Invited Commentary: “Histiocytosis X”.  Thorax 1998;53:322-323. Available at: http://link.springer.com/chapter/10.1007%2F978-1-4615-1959-1_21

Gorog, D.A., Rakhit, R., Parums, D.V., Laffan, M., Davies, G.J. Raised Factor VIII is Associated with Coronary Thrombotic Events. Heart 1998;80:415-7. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9875127

Marchbank, A.J., Parums, D.V., Westaby, S. Tricuspid Valve Repair in a Mountaineer. Ann Thorac Surg 1998;65:537-9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9485262

Leonard A, Corris P, Parums, D.V.  Amiodarone pulmonary toxicity. BMJ  1997;314:1831-1832. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9224103

Walton, L.J., Powell, J.T., Parums, D.V. Unrestricted Usage of Immunoglobulin Heavy Chain Genes in B Cells Infiltrating the Wall of Atherosclerotic Abdominal Aortic Aneurysms. Atherosclerosis  1997 135: 65-71. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9395274

Douek, M., Kitson, J.L., Parums, D.V., Coombs, R.R.H. The value of modern imaging in the diagnosis of foot swellings. The Foot 1996;6:152-157. Available at: http://www.worldcat.org/title/the-value-of-modern-imaging-techniques-in-the-diagnosis-of-foot-swellings/oclc/4933650049&referer=brief_results

Buttery, L.D.K., Springall, D.R., Chester, A.H., Evans T.J., Standfield, N, Parums, D.V., Yacoub, M.H., Polak, J.M. Inducible Nitric Oxide Synthase is Present within Human Atherosclerotic Lesions and Promotes the Formation and Activity of Peroxynitrite. Lab Invest 1996;75:77-85. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8683942

Parums DV, Ashton MD, Mason JC, Haskard DO.Thy-1 expression by new vessels associated with atherosclerosis. Journal of Pathology. 1996:179, ISSN:0022-3417. Pages:A46-A46

Dr Dinah Parums, Senior Lecturer, RPMS, Hammersmith Hospital, 1996

Dr Dinah Parums, Senior Lecturer, RPMS, Hammersmith Hospital, 1996

Kennedy, P., Parry, A.J., Parums, D.V., Pillai, R. Myxoma of the aortic valve. Ann Thorac Surg. 1995; 59: 1221-3. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7733728

Ramshaw, A.L., Roskell, D.E., Parums, D.V. Cytokine gene expression in  aortic adventitial inflammation associated with advanced atherosclerosis (chronic periaortitis).  J Clin Pathol  1994;47: 721-727. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7962625

Parums, D.V. Invited review; the arteritides. Histopathology  1994;25:1-20. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7959641

Potter, C.G., Ramshaw, A.L., Stickland, J.E., Parums, D.V., McGee, J.O’D. Quantification of specific mRNA by flat-bed scintillation counting of dual-labelled dot blots. Biotechniques  1993;15:738-43. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8251177

Wood, K.M., Cadogan, M.D., Ramshaw, A.L., Parums, D.V. The distribution of adhesion molecules in human atherosclerosis. Histopathology  1993;22: 437-444. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7688340

Dr Dinah Parums. Double immunohistochemistry showing T cells (brown) migrating through endothelium (red).

Dr Dinah Parums. Double immunohistochemistry showing T cells (brown) migrating through endothelium (red).

Ramshaw, A.L., Parums, D.V. The distribution of adhesion molecules in chronic periaortitis. Histopathology 1994;24:23-32. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7511559

Paul, J., Baigrie, C., Parums, D.V. A fatal case of disseminated infection with the turtle bacillus, Mycobacterium chelonae J.Clin Pathol  1992;45:528-530. Available at: http://www.ncbi.nlm.nih.gov/pubmed/1624602

Davies, A.H., Parums, D.V. Storage of donor long saphenous vein for coronary artery bypass surgery. J Cardiovascular Surgery  1992;33:92-97. Available at: http://www.ncbi.nlm.nih.gov/pubmed/1545005

Ramshaw, A.L., Parums, D.V. Combined immunohistochemical and immunofluorescence method to determine the phenotype of proliferating cell populations. J Clin Pathol 1992;45:1015-1017. Available at: http://www.ncbi.nlm.nih.gov/pubmed/1485903

Dr Dinah Parums. A combined immunohistochemistry and immunofluorescence method showing CD31 positive endothelial cells (green) and HLA-DR positive cells (red) with 'activated' endothelial cells yellow.

Dr Dinah Parums. A combined immunohistochemistry and immunofluorescence method showing CD31 positive endothelial cells (green) and HLA-DR positive cells (red) with ‘activated’ endothelial cells yellow.

Parums, D.V., Choudhury, R.P., Shields, S.A., Davies, A.H. Characterization of inflammatory cells associated with “idiopathic retroperitoneal fibrosis”.  Br J Urol  1991;67:564-568. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2070198

McKee, G., Parums D.V.  False positive cytodiagnosis in fibrosing alveolitis. Acta Cytologica 1990;34:105 107. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2296835

Cawthorn, S.J., Parums, D.V., Gibbs, N.M., A’Hern, R.P., Caffarey, S.M., Broughton, C.I.M., Marks C.G. Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal carcinoma. Lancet  1990;335:1055-1059. Available at: http://www.ncbi.nlm.nih.gov/pubmed/1691810\

Parums, D.V., Dunn, D.C, Dixon, A.K, Mitchinson, M.J. Characterization of inflammatory cells in a patient with chronic periaortitis.  Am J Cardiovascular Pathol  1990;3:121-129. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2264985

Parums, D.V. Inflammatory mediators and atherosclerosis. Biochem Soc Trans  1990;18:1069-1072. Available at: http://www.biochemsoctrans.org/bst/018/bst0181069.htm

Parums, D.V., Brown, D.L., Mitchinson, M.J. Serum antibodies to oxidized LDL and ceroid in chronic periaortitis. Arch Pathol Lab Med 1990;114:383-387. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2322097

Parums, D.V. The spectrum of chronic periaortitis. Histopathology 1990;16:423-431. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2193863

Dr Dinah Parums. Photomicrograph of chronic periaortitis - advanced atherosclerosis, medial thinning and chronic adventitial inflammation.

Dr Dinah Parums. Photomicrograph of chronic periaortitis – advanced atherosclerosis, medial thinning and chronic adventitial inflammation.

Ramshaw, A.L., Parums, D.V. Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosis. Histopathology 1990;17:543-552. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2076887

Parums, D.V., Cordell, J.L., Micklem, K., Heryet, A.R., Gatter, K.C., Mason, D.Y.  JC70 : A new monoclonal antibody that detects vascular endothelium-associated antigen on routinely processed tissue sections.  J Clin Pathol  1990;43:752-757. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2212067

Parums, D.V.  Studies on Inflammation in Atherosclerosis.  PhD thesis, University of Cambridge, 1987. Available at: http://ulmss-newton.lib.cam.ac.uk/vwebv/holdingsInfo?bibId=12418

Dr Dinah Parums, Research Fellow in Pathology, Darwin College, Cambridge University, 1986

Dr Dinah Parums, Research Fellow in Pathology, Darwin College, Cambridge University, 1986

Parums, D.V., Chadwick, D.R., Mitchinson, M.J. The localisation of immunoglobulin in chronic periaortitis. Atherosclerosis 1986;61:117-123. Available at: http://www.sciencedirect.com/science/article/pii/0021915086900705

Parums, D.V., Mitchinson, M.J. Demonstration of immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis 1981;38:211-216. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7470201

Dinah Parums, Part II Pathology student, University of Cambridge, Department of Pathology, 1979/80

Dinah Parums, Part II Pathology student, University of Cambridge, Department of Pathology, 1979/80

ONLINE LIFE SCIENCE AND HEALTHCARE ARTICLES

Dr Dinah V. Parums

I. Individual Contributor at Thomson Reuters Life Sciences Connect, 

2014 / 2015: http://lsconnect.thomsonreuters.com/author/dinah-parums/

26th May 2015:

‘Indigenous’ Human Microbes – the Microbiota and the Microbiome. http://lsconnect.thomsonreuters.com/indigenous-human-microbes-the-microbiota-and-the-microbiome/

25th Feb 2015:

CARs (Chimeric Antigen Receptors): Where Are They Taking Us? https://lsconnect.thomsonreuters.com/cars-chimeric-antigen-receptors-taking-us/

17th Feb 2015:

Can Accelerated Drug Approval in Oncology Go Any Faster? https://lsconnect.thomsonreuters.com/can-accelerated-drug-approval-oncology-go-faster/

9th Feb 2015:

Lipids Actually – A Year of Advances in Hyperlipidaemia Therapy. https://lsconnect.thomsonreuters.com/lipids-actually-year-advances-hyperlipidaemia-therapy/

21st October 2014:

A Dendritic Cell ‘Vaccine’ is a First for ‘Promising Innovative Medicine’ (PIM) Status in the U.K. http://lsconnect.thomsonreuters.com/dendritic-cell-vaccine-first-promising-innovative-medicine-pim-status-u-k/

7th October 2014:

‘Back to the Future:’ Bioimmunoadjuvants in Cancer Therapy.  https://lsconnect.thomsonreuters.com/back-future-bioimmunoadjuvants-cancer-therapy

22nd July 2014:

The ‘Danger Theory’ of Immune Recognition: 60 years on from ‘Self, Non-Self’. https://lsconnect.thomsonreuters.com/danger-theory-immune-recognition-60-years-self-non-self/

19th June 2014:

The Role of the Pathologist in Targeting Therapy in NSCLC. https://lsconnect.thomsonreuters.com/role-pathology-in-nsclc-targeting-therapy/

11th June 2014:

Targeted Therapy in NSCLC Part VI: Immune Therapy. https://lsconnect.thomsonreuters.com/targeted-therapy-nsclc-part-vi-immune-therapy/

27th May 2014:

Targeted Therapy in NSCLC Part IV: ALK. http://lsconnect.thomsonreuters.com/targeted-therapy-nsclc-part-iv-alk/

21st May 2014:

Targeted Therapy in NSCLC Part III: VEGF/VEGFR. http://lsconnect.thomsonreuters.com/targeted-therapy-nsclc-part-iii-vegf-vegfr/

14th May 2014:

Targeted Therapy in NSCLC Part II: EGF/EGFR. http://lsconnect.thomsonreuters.com/targeted-therapy-nsclc-part-ii-egf-egfr/

6th May 2014:

Targeted Therapy in Non Small Cell Lung Cancer (NSCLC). Part I. Biologics. http://lsconnect.thomsonreuters.com/biologics-non-small-cell-lung-cancer-nsclc-part-current-status-2014/

9th April 2014:

Dietary Fats vs. Carbohydrates and Coronary Artery Atherosclerosis http://lsconnect.thomsonreuters.com/dietary-fats-vs-carbohydrates-coronary-artery-atherosclerosis/

2nd April 2014:

L-Carnitine and Ischaemic Heart Disease: A Story of ‘Mice and Men’ http://lsconnect.thomsonreuters.com/l-carnitine-ischaemic-heart-disease-story-mice-men/

18th March 2014:

‘Crowdfunding’ and its Supporting Role in Life Science and Healthcare Projects. http://lsconnect.thomsonreuters.com/crowdfunding-life-sciences/

12th March 2014:

What’s TRND-ing ? NIH Division of Pre-Clinical Innovation, subdivision of Therapeutics for Rare and Neglected Diseases (TRND). http://lsconnect.thomsonreuters.com/whats-trnd-ing-nih-division-pre-clinical-innovation-subdivision-therapeutics-rare-neglected-diseases/

5th March 2014:

Collaboration Between the NIH, ‘Big Pharma’ and Non-Profit Organizations http://lsconnect.thomsonreuters.com/collaboration-nih-big-pharma-non-profit-organisations/

24th February 2014:

The National Center for Advancing Translational Sciences (NCATS): We May Be No Longer ‘Lost in Translation’ http://lsconnect.thomsonreuters.com/national-center-advancing-translational-sciences-ncats-may-longer-lost-translation/

II. LinkedIn Pulse

14th August 2015:

Medical Journalism: time for involvement by the medical profession. By Dr Dinah Parums  https://www.linkedin.com/pulse/medical-journalism-time-involvement-profession-dinah-parums

13th August 2015:

Good Publication Practice Guideline 3 (GPP3). August 2015. By Dr Dinah Parums

https://www.linkedin.com/pulse/good-publication-practice-guideline-3-gpp3-august-2015-dinah-parums?trk=prof-post

III. Contributing Author. Healthcare-Arenapublished by Pentland Medical. Original Articles 

https://healthcare-arena.co.uk/author/dinahparums/

11th August 2015:

Is There a Role for Humour in Medicine? By Dr Dinah Parums. If so, what is it? For Healthcare-Arena. Illustrated by Fran Orford

https://healthcare-arena.co.uk/is-there-a-role-for-humour-in-medicine/

27th July 2015:

Chronic Hepatitis C Infection. By Dr Dinah Parums. NHS England has now agreed to increase the funding of new treatments. For Healthcare-Arena. Illustrated by Fran Orford. https://healthcare-arena.co.uk/chronic-hepatitis-c-infection/

27th July 2015:

The NHS Goes Back to the Future in 2015. By Dr Dinah Parums. NHS England’s CEO outlines the implementation of the ‘Five Year Forward View’ at this year’s NHS Confederation conference. For Healthcare-Arenahttps://healthcare-arena.co.uk/the-nhs-goes-back-to-the-future-in-2015/

27th July 2015:

Meningitis B Vaccine. By Dr Dinah Parums. England and Scotland are first to implement a national vaccination programme: but who will follow? For Healthcare-Arena.  https://healthcare-arena.co.uk/meningitis-b-vaccine/

27th July 2015:

Social Prescribing. By Dr Dinah Parums. See your GP and leave with a prescription for a pet or a new hobby? For Healthcare-Arena. Illustrated by Fran Orford. https://healthcare-arena.co.uk/social-prescribing/

20th July 2015:

Treatment for Advanced Melanoma Using T-VEC. By Dr Dinah Parums. A Herpes Simplex Virus Type 1-derived oncolytic immunotherapy: – separating fact from fiction. Illustrated by Fran Orford. https://healthcare-arena.co.uk/treatment-for-advanced-melanoma-using-t-vec/

20th July 2015:

Personalised Microbial Health. By Dr Dinah Parums. Microbiome data now being gathered may form the basis for a ‘personalised’ approach to improving individual microbial populations. https://healthcare-arena.co.uk/personalised-microbial-health/

20th July 2015:

The Carter Review. Procurement in the NHS. By Dr Dinah Parums. Standardisation is predicted to save the NHS £5bn a year by 2020. https://healthcare-arena.co.uk/the-carter-review-procurement-in-the-nhs/

20th July 2015:

Carbapenem-Resistant Enterobacteriaceae (CRE): an Update. By Dr Dinah Parums. Antimicrobial Research Collaborative (ARC) recommends CRE screening as a priority for admissions to high-risk specialties. https://healthcare-arena.co.uk/carbapenem-resistant-enterobacteriaceae-cre/

IV. Marketing Product Insights – for Pentland Medical

11th August 2015:

ABLiS™ – Antimicrobial Basin and Liner System. Pentland Medical Product Insight written by Dr Dinah Parums. An innovative bed-bathing system providing cost-effective comfort and prevention of healthcare-associated infection (HAI). https://healthcare-arena.co.uk/ablis-antimicrobial-basin-and-liner-system/

27th July 2015:

Medspira Breath Hold. Pentland Medical Product Insight written by Dr Dinah Parums. Safe, reliable, accurate and affordable respiratory control technology to protect patients during imaging and radiotherapy. https://healthcare-arena.co.uk/medspira-breath-hold/

20th July 2015:

The Nasal Alar SpO2 Sensor. Pentland Medical Product Insight written by Dr Dinah Parums. Accurate long-term pulse oximetry monitoring with greater patient comfort, lower cost and application beyond the ICU.  https://healthcare-arena.co.uk/the-nasal-alar-spo2-sensor/

MEETING PRESENTATIONS & ABSTRACTS (1985 to 2007):

2007:

Donovan, M.J., Kotsianti, A., Bayer-Zubek, V., Verbel, D., Clayton, M., Hamann, S., Capodieci, P., Pang, H., Cordon-Cardo, C., Parums, D., Holloway, B.

A systems pathology model for predicting overall survival in patients with refractory, advanced non small cell lung cancer (NSCLC) treated with gefitinib. ASCO Annual Meeting Proceedings 2007, 25(18): 18065.

2005:

Wookey, A, Ellison, G, Donald, E, McCormick, R, Smith, J, Parums, D, Flannery, A, Gibson, N, March, R. Genetic Heterogeneity of Tumours and implications for Epidermal Growth Factor Receptor Mutation Detection in Non Small Cell Lung Cancer Patients. Abstract and Poster 3390. AACR, April 2005.

http://www.abstractsonline.com/viewer/viewAbstract.asp?CKey={B74B45DA-99A5-4496-A2EA-8A525AD0A1C3}&MKey={218FF7E7-9F17-4030-9BB4-8C029B0C9B4E}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}&SKey={7CE4DF10-EEC9-4132-B659-5BBF3C75C385

2001:

Torsney, E., Charlton, R.G., Arthur, H. Parums, D.V. Endoglin, a gene required for murine embryonic vasculogenesis is upregulated in angiogenesis in human inflammatiory disease: studies using a ‘knockout’ mouse model (the ‘Cookson Mouse’). J Pathol 2001, 193: 9A-9A.

Katz, S.D., Parums, D.V. Sympathetic activity by sildenafil. Circulation 2001, 104(22):e119-e120.

Charlton, R.G., Parums, D.V. Transforming growth factor-beta1 (TGF-bet1) expression by myofibroblasts in dermal wound healing. J Pathol 2001, 193: 8A-8A.

2000:

Charlton, R.G.,Thompson, L., Phillips, S., Ridden, J., Cindrova, T., Johnson, N., Parums, D.V. LIP-1 (PDE-5A1); A marker for human smooth muscle cells and myofibroblasts. J Pathol 2000, 192: 27A-27A.

Parums, D.V., Charlton, R.G., Johnson, N., Cindrova, T., Skepper, J., Phillips, S. Immunohistochemistry (IHC), in situ hybridization (ISH) and biochemical characterization of phosphodiesterase type 5 (PDE5) in normal and ischaemic cardiac tissue. European Heart Journal 2000, 21: 616-616.

Torsney, E., Charlton, R.G., Arthur, H., Parums, D.V. An antibody to endoglin/CD105 (SN6h): a marker for endothelial cells in chronic inflammatory disease. J Pathol 2000, 192: 27A-27A.

Charlton, R.G., Parums, D.V. Characterisation of the cellular components of chronic skin wounds: the role of cytokines (VEGF, bFGF and TGFbeta) in angiogenesis and fibrosis. J Pathol 2000, 192: 30A-30A.

* (Winner of the July 2000 Poster Prize from the Pathological Society of Great Britain & Ireland)*

1999:

Charlton, R., Thompson, L., Turley, H., Gatter, K., Parums, D.V. A new monoclonal antibody to VEGF (VG1) can be used to study angiogenesios in fixed material. J Pathol 1999, 187: 36A-36A.

Parums, D.V., Ashton, M., Charlton, R., Holter, J., Ridden, J. Novel endothelial cell markers are expressed in angiogenesis in human atherosclerosis. J Pathol 1999, 187: 12A-12A.

Charlton, R., Holter, J., Ridden, J., Thompson, L., Parums, D.V. The expression of C5a receptor (C5aR)(CD88) is associated with the progression of inflammation in human disease. J Pathol 1999, 187: 36A-36A.

1998:

Parums, D.V., Walton, L.J., Powell, J.T. Unrestricted usage of immunoglobulin heavy chain genes in adventitial B-lymphocytes in atherosclerotic aortic aneurysms. J Pathol 1998, 184: 32A-32A.

Jalini, L., Angus, B., Parums, D.V. Post-transplant lymphoproliferative disease (PTLD) in heart and lung transplant patients at the Freeman Hospital. J Pathol 1998, 184: 35A-35A.

Charlton, R.G., Neal, D.E., Morley, A.R., Parums, D.V. A morphometric study of nerve, muscle and connective tissue in the ‘unstable’ bladder. J Pathol 1998, 184: 40A-40A.

1997:

Parums, D.V., Martin, A., Belgore, F., Chung, N. Angiogenesis is associated with the progression of human atherosclerosis to clinically significant disease. J Pathol 1997, 182: A13-A13.

Kumar, R., Smith, D.A., Parums, D.A. Cytopathology, immunohistochemistry and electronmicroscopy in the diagnosis of a case of epithelioid haemangio-endothelioma (EHE) of the lung. J Pathol 1997, 182: A28-A28.

Parums, D.V., Chung, N., Ludbrook, V., Houston, P., Campbell, C.J., Wells, T.N.C. Specific chemokine receptors are associated with angiogenesis and leukocyte recruitment in human atherosclerosis. J Pathol 1997, 82: A13-A13.

Parums, D.V., Pignatelli, M. The localization of novel endothelial cell (EC) markers in angiogenesis in human atherosclerosis. J Pathol 1997, 182: A41-A41.

Johnson, N., Ashcroft, T., Parums, D.V. The role of calretinin in the diagnosis of mesothelioma. J Pathol 1997, 182: A28-A28.

1996:

Walton, L.J., Parums, D.V., Powell, J.T. B cells infiltrating abdominal aortic aneurysms are polyclonal. Immunology 1996, 89: BB304-BB304.

Parums, D.V., Pignatelli, M. Localisation of novel endothelial cell markers in human advanced atherosclerosis. Tissue Antigens 1996, 48(4-II): EC105-EC105.

Ashton, M.D., Parums, D.V., Standfield, N. Characterisation of arterio-venous malformation (AVM). J Pathol 1996, 179: A47-A47.

Parums, D.V., Chung, N., Belgore, F. Tumour necrosis factor alpha (TNF-alpha) is involved in the progression of human atherosclerosis. J Pathol 1996, 179: A46-A46.

Parums, D.V., Chung, N., Ludbrook, V., Houston, P., Black, D., Wells, T. The localization of novel chemokine receptors in human atherosclerosis. J Pathol 1996, 179: A46-A46.

Parums, D.V., Ashton, M.D., Mason, J.C., Haskard, D.O. Thy-1 expression by new vessels associated with atherosclerosis. J Pathol 1996, 179: A46-A46.

1995:

Parums, D.V. The Distribution of Adhesion Molecules in Normal and Atherosclerotic Arteries and Aortas. In: Cardiovascular Disease; Cellular and Molecular Mechanisms, Prevention, and Treatment. Ed. Gallo, L.L. 1995, 159-172.

http://link.springer.com/chapter/10.1007%2F978-1-4615-1959-1_2

1994:

Parums, D.V., Ramshaw, A.L. Expression of adhesion molecules and cytokine genes in aortic adventitial chronic inflammation associated with advanced atherosclerosis (chronic periaortitis). Journal of Cellular Biochemistry 1994, 56: 298-298.

1991:

Ramshaw, A.L., Stickland, J.E., Baigrie, R.J., Parums, D.V. Cytokine and cytokine receptor expression associated with advanced atherosclerosis. J Pathol 1991, 164(4): A348-A348.

Ramshaw, A.L., Parums, D.V. Inflammatory cells in chronic periaortitis are activated and proliferating. J Pathol 1991, 163(2): A162-A162.

1990:

Ramshaw, A.L., Parums, D.V. Immunohistochemical characterization of inflammatory cells in biopsies from atherosclerotic abdominal aortic aneurysms. J Pathol 1990, 160(2): A160-A160.

Parums, D.V. Inflammatory mediators in atherosclerosis. Biochem Soc Trans 1990, 18: 1069-1072.

http://www.biochemsoctrans.org/bst/018/bst0181069.htm

1987:

Parums, D.V., Mitchinson, M.J. Serum antibodies to oxidized LDL and ceroid in chronic periaortitis. J Pathol 1987, 151(1): A57-A57.

1985:

Parums, D.V., Mitchinson, M.J. Auto-Allergy in Atherosclerosis. J Pathol 1985, 146(3): A245-A245.